Jose Mourinho has named a strong attack featuring Zlatan Ibrahimovic, Anthony Martial, Henrikh Mkhitaryan and Paul Pogba for Sunday's clash with Liverpool.
Marcos Rojo starts alongside Phil Jones in the centre of defence while Matteo Darmian is selected ahead of Daley Blind.
Ibrahimovic has missed the last two competitive fixtures having been rested for the FA Cup trouncing of Reading before sitting out the EFL Cup win over Hull City through illness, but he has recovered sufficiently to lead United's line at Old Trafford.
Meanwhile Rojo returns in defence having been forced off early against Reading with a muscle injury and having Chris Smalling replace him for the midweek League Cup clash.
Jordan Henderson has shaken off a heel injury to lead Liverpool out, but Nathaniel Clyne misses out through a knock with Philippe Coutinho named on the bench.
The captain has sat out the last three games, with Jurgen Klopp’s side failing to win any of them in his absence.
His return at Old Trafford on Sunday provides Jurgen Klopp with a weighty boost, but the manager is minus the service of Clyne at right-back, with 18-year-old Trent Alexander Arnold earning his first Premier League start as a result.
Elsewhere in defence, Joel Matip was withdrawn from selection consideration as the Reds await clarity from FIFA over his eligibility while the Africa Cup of Nations is on.
Coutinho, who ended a 46-day absence with a cameo in the 1-0 League Cup semi-final, first-leg defeat at Southampton, is once again among the substitutes.
Manchester United XI: De Gea, Valencia, Jones, Rojo, Darmian, Carrick, Herrera, Pogba, Mkhitaryan, Martial, Ibrahimovic
Subs: Romero, Mata, Rooney, Smalling, Blind, Rashford, Fellaini
Liverpool XI: Mignolet, Alexander-Arnold, Klavan, Lovren, Milner, Henderson, Wijnaldum, Can, Lallana, Firmino, Origi
Subs: Karius, Gomez, Moreno, Stewart, Ejaria, Coutinho, Sturridge