Gabriel Jesus has been selected ahead of Sergio Aguero to lead the Manchester City line against Swansea on Sunday.
The Brazilian scored one and set one up in City's 4-0 victory at West Ham last time out and forces Aguero to watch from the sidelines once again.
Guardiola has opted for a three-man defence at the Etihad against Paul Clement's side, who come into the game with two consecutive wins, with Gael Clichy, John Stones and Alexsander Kolorov across the back.
The tactical switch sees Yaya Toure alongside the returning Fernandinho, with Raheem Sterling and Leroy Sane in the wide areas for the home side. Kevin De Bruyne and David Silva provide additional firepower behind the in-form Jesus.
Willy Cabellero continues between the sticks following a strong performance against the Hammers last week.
Clement has named an unchanged Swansea side for their trip to Manchester, with Fernando Llorente continuing as the focal point in attack.
A midfield-three of Jack Cork, Leroy Fer and Tom Carroll, with Gylfi Sigurdsson and Wayne Routledge in advanced roles, will meet Guardiola's side.
Man City: Caballero; Stones, Kolarov, Clichy; Fernandinho, Toure; Sterling, De Bruyne; Silva (C), Sane; G. Jesus
Man City subs: Bravo, Kompany, Zabaleta, Fernando, Aguero, Navas, Delph
Swansea: Fabianski; Naughton, Fernandez, Mawson, Olsson; Carroll, Fer, Cork; Routledge, Sigurdsson, Llorente
Swansea subs: Nordfeldt, Kingsley, Amat, Britton, Narsingh, Dyer, Borja