Although they drew blank, the Jacks equally prevented Middlesbrough from scoring as both sides shared the spoils in the Premier League fixture at the Liberty Stadium.
In Llorente's absence, Ayew was handed a rare start, playing as the target man in attack, aided by Luciano Narsingh and Gylfi Sigurdsson.
“We missed Fernando – he is a big focal point for us,” Clement said, as reported by his club's official website.
“That is not to say Jordan Ayew did not play well. He gave us another dynamic that Fernando doesn’t have.
“But of course Fernando is a miss. He has an ankle issue that I am hoping will not keep him out for long. Wednesday, [a win against Tottenham Hotspur] is achievable, although he is still a doubt for that game.
“He has a chance, but we are very much looking at him day to day.”
Sunday's result leaves Swansea still on the 17th position, just a spot above the relegation zone.
“We have to win games and we haven’t done that in the last three,” Clement added.
“We are disappointed about that, but we have put a point on the board and we will have to see if that is really valuable or not enough at the end of the season.”
Ayew has so far made six appearances involving two starts for Swansea since a January transfer from Championship outfit Aston Villa.