Atletico have had to play their first three La Liga matches on the road as they wait for their new stadium to be completed and Diego Simeone's men begin their Champions League campaign also on their travels, with the beaten finalists from 2014 and 2016 heading to the Stadio Olimpico to face Roma.
With Chelsea also in Group C the battle to secure qualification to the knockout stages should be a keenly contested one, and while Atletico are favorites to join Chelsea in the last 16, Roma, who return to the competition after missing out last season, will feel they have a chance.
The Italian outfit will have to significantly improve their home record, however, with the Giallorossi winning just one of the last seven matches they have hosted in the Champions League. Bet365 make them slight outsiders at 17/10 (2.70), while Atletico are priced at 13/8 (2.62) and in recent years the Madrid side have been excellent in the group stages.
That Atleti have situated themselves among Europe's elite for the last few years has been thanks in large part to their solid defence, and away from home particularly they tend to keep things extremely tight.
Under 2.5 goals is offered at just 61/100 (1.61) and six of Atletico's last eight away games in the group stages of this competition have seen fewer than three goals, with five of those eight games seeing fewer than two goals and under 1.5 goals is offered at a more tempting looking 7/4 (2.75).
There is also serious value to be had in backing Atletico to win and under 2.5 goals scored at 4/1 (5.00) with Simeone's side experts at seeing out low scoring wins on the road; of the last five
matches they have won away from home in the group stages, four of them have come with less than three goals in the game and the price quoted offers punters the chance to make a healthy profit.