Real Madrid start the defence of their Liga title with a trip to Deportivo La Coruna on Sunday.
Zinedine Zidane's side claimed the Primera Division last season after edging out Barcelona and Los Blancos, fresh from their UEFA Super Cup and Spanish Supercopa successes this month, have now won seven titles under the French coach.
In his 19 months in charge, Zidane has overseen only seven defeats and his side will be confident of success in this match after a 5-1 aggregate win over Barcelona in the Supercopa this week.
Here, Goal takes a look at everything you need to know ahead of Madrid's match in Galicia...
REAL MADRID INJURIES
Defender Jesus Vallejo is injured for Real Madrid and will play no part against Deportivo, while Mateo Kovacic trained alone and is doubtful. Coach Zinedine Zidane has an otherwise fully fit squad at his disposal.
REAL MADRID SUSPENSIONS
Cristiano Ronaldo received a five-match ban for his red card and push on the referee in the first leg of the Spanish Supercopa at Camp Nou on Sunday night.
The Portuguese sat out the second leg at the Santiago Bernabeu on Wednesday, but will serve the remainder of his suspension in La Liga - starting with the match against Deportivo.
REAL MADRID POTENTIAL STARTING LINE-UP
Gareth Bale and Isco both look set to return to the starting line-up after playing no part in Real Madrid's 2-0 win at home to Barcelona on Wednesday.
The two players were in the starting XI at Camp Nou on Sunday and should now return to the team as Cristiano Ronaldo misses the trip to Riazor through suspension.
Elsewhere, coach Zinedine Zidane has plenty of options and could consider handing full debuts to summer signings Dani Ceballos and Theo Hernandez.
DEPORTIVO TEAM NEWS
Deportivo coach Pepe Mel has said that he would be happy with a goalless draw against Real Madrid at the weekend.
Mel, who is hoping to sign Lucas Perez from Arsenal, could be without striker Florian Andone for this match as the Romanian is suffering from a muscle strain in his left leg.
Carles Gil is also sidelined, while Turkish international Emre Colak is suspended and Fede Valverde is ineligibile due to a clause in his loan agreement with parent club Madrid.
BEST OPTA MATCH FACTS
Deportivo have lost 12 and drawn one of their last 13 league games against Real Madrid. The Galicians' last win against Los Blancos was on the opening day of the 2008-09 season (2-1).
After 17 trips to Riazor in La Liga without a win between 1992 and 2008 (drawing five and losing 12), Real Madrid have won five of their last six (and drew the other).
Madrid won 8-2 against Deportivo at Riazor in September 2014, their biggest ever away win in La Liga
Isco has scored more goals in La Liga in 2017 than any other midfielder (eight). Meanwhile, Gareth Bale has gone 372 minutes without a goal in La Liga, his longest drought in 2017.
UK TV COVERAGE & KICK-OFF TIME
Deportivo versus Madrid kicks off at 22:15 CEST at Riazor and will be shown live from 21:10 UK time on Sky Sports Football.