Nigeria face Stuart Baxter’s men at the Godswill Akpabio Stadium in their quest for a ticket to 2019 Afcon.
And still fresh from Bafana Bafana stopping the three-time African champions from qualifying for Equatorial Guinea 2015, the defender is optimistic of qualifying for Cameroon.
Nevertheless, he is adamant Baxter’s men have what it takes to cause Nigeria problems if they are not fully focused.
''When it comes to African football, South Africa have a good team and they play fast football. Each time we play them it has never been easy,'' Echiejile told media during Thursday’s media parley.
''We don’t have to think about them stopping us from the Nations Cup [Equatorial Guinea 2015], all we want is play the next Afcon.
''This is our first game and we have to start very well because we are playing a very good side.
''All we have to do is concentrate on the game tactically, give everything and hope for a good result.''