The on-loan Crystal Palace man lasted the entire duration on his international debut but it was not the best of days at the office as the Netherlands were handed a 4-0 away defeat by France in 2018 World Cup qualifying.
Fosu-Mensah's outing means he is no more eligible for a nationality switch, dashing Ghana's hopes of roping in the youngster.
Born to Ghanaian parents in Amsterdam, he was eligible to complete a one-time nationality switch to turn out for the Black Stars, having played for Oranje at various youth levels.
The starlet has long been on the radar of Ghana, with GFA officials and representatives of the player confirming making contacts over a change of international allegiance.
There could be more bad news for Ghana on Saturday as two other targets are in line to make competitive appearances for European sides.
Augsburg’s Kevin Danso has been handed another senior call-up by Austria, having failed to earn a cap on his maiden invite in May.
The 18-year-old could make his debut against Wales on September 2 or Georgia three days later in the World Cup qualifiers.
Uncapped new Chelsea recruit Ethan Ampadu, 16, has likewise earned another call-up to Wales’ senior side after receiving his first invite in May.
Also eligible to represent England, Ireland and Ghana, Ampadu could end the international tussle for his services when Chris Coleman’s outfit face Austria on September 2 or Moldova three days later in World Cup qualifying.