After three straight wins in all competitions, Jurgen Klopp's side are looking to maintain their good recent form against Southampton.
The Reds have a record agains the Saints in recent years, however, and not picking up all three points would see them fall further behind those at the top of the table.
Southampton, meanwhile, have struggled for consistency under Mauricio Pellegrino but will certainly be a tough nut to crack for the Merseyside outfit.
Sadio Mane withdrew from Senegal's squad ahead of their clash with South Africa amid fears he has suffered a reoccurence of his recent hamstring injury.
Jordan Henderson also missed out during the international break with a thigh injury but has since returned to full training and is in contention.
Long-term absentee Nathaniel Clyne will not return until 2018 having undergone back surgery, but Adam Lallana could make his first appearance of the season having recovered from a thigh injury.
Neither side has any players missing through suspension.
LIVERPOOL POTENTIAL STARTING LINE-UP
Mane's injury means Philippe Coutinho could again move forward to join Mohamed Salah and Roberto Firmino up front having come through Brazil's clash with England unscathed.
That could allow Alex Oxlade-Chamberlain to retain his place in the starting XI having found the net against West Ham last time out.
Having impressed for England in midweek, Joe Gomez will likely start ahead of Trent Alexander-Arnold at right-back while Dejan Lovren should be fit to return.
SOUTHAMPTON TEAM NEWS
The Saints are hopeful Mario Lemina will have recovered from an ankle injury to take his place in midfield alongside Oriol Romeu.
His return could be offset by an injury to fellow summer signing Wesley Hoedt, however, with the centre-back having pulled out of the Netherlands squad with a knee injury over the break from domestic action.
Hoedt's absence will likely mean Liverpool target Virgil van Dijk will be partnered by Maya Yoshida at the heart of the defence.
BEST OPTA MATCH FACTS
Southampton are unbeaten in their last five games in all competitions against Liverpool; they have never gone six in a row without defeat (W3 D2 L0).
The Reds haven’t failed to score against a single team in five consecutive meetings in all competitions since 1978 versus Nottm Forest.
Liverpool have conceded 30 goals via set-pieces in the Premier League since Jurgen Klopp took charge in October 2015 - only Watford (36), Stoke (32) and Crystal Palace (31) have conceded more.
No player has scored more goals after their first 11 Premier League games for Liverpool than Mohamed Salah (7 – level with Daniel Sturridge). Only Robbie Fowler scored eight goals in his first 12 Premier League games for Liverpool.
TV COVERAGE & KICK-OFF TIME
Kick off is 15:00 GMT with the game not being shown live in the UK. Highlights will be shown on Match of the Day on BBC One at 22:20.