The equation is simple for Leicester City - they either score against one of the staunchest defences in European football or their Champions League fairy tale comes to an end.
bet365 go 14/5 (3.80) that the Premier League champions win the second leg, while the draw is 5/2 (3.50) with the same firm and Atletico Madrid are 11/10 (2.10) to complete back-to-back wins over the Foxes.
It's no surprise to see the Spanish side as heavy 1/8 (1.12) favourites to qualify, while bet365 go 5/1 (6.0) that the hosts pull off another impressive European comeback at the King Power Stadium and secure a spot in the semi-finals.
It will be a special atmosphere in the East Midlands but the home side will need to find their shooting boots as well as keeping the likes of a rested Antoine Griezmann and his team-mates at arms' length if they are to keep their European dream alive. It's 19/20 (1.95) that both teams score and 4/5 (1.80) that one or both fail to find the net.
Craig Shakespeare's side will feel aggrieved at the penalty decision that led to the only goal in Madrid, but Atleti demonstrated their ability to shut down games once in front and that could be the key to a wager here.
The Foxes know they'll need to find a breakthrough but taking the game to the two-time Champions League finalists is a dangerous approach and one that could expose a backline missing Robert Huth and potentially Wes Morgan, who has been out with a back injury of late.
It's 11/10 (2.10) that the second half contains the most goals and that is not without appeal given the way this clash is set up but it could be worth taking a chance on a bigger price from another market involving goals after the break.
While it may start as something of a chess match, as the game wears on, Leicester are like to have to take more chances and that could mean there's some value in the 6/4 (2.50) available on Atletico scoring more goals in the second half than the first.
Simeone will surely instruct his side to soak up the pressure in the early exchanges, knowing that the Foxes will become more and more desperate for a breakthrough. That makes the 6/4 (2.50) on Atleti scoring more goals in the second half than they do before the break look like a fine wager for this delicately poised quarter-final second leg.