Mauricio Pellegrino has been sacked as Southampton manager with just eight games left of the Premier League campaign. Saints sit 17th in the table, just one place and one point above the relegation zone, having won just once in their previous 17 top flight matches.
dabblebet now make Saints 15/8 (2.88) to go down in their latest Premier League relegation odds.
The club achieved an eighth-place finish last season as well as reaching the final of the League Cup but Claude Puel - now in charge at Leicester City - was sacked, with sections of the fanbase unhappy with his choice of playing style.
Mark Hughes and Marco Silva have both been linked with the vacancy having been sacked from Premier League jobs over the course of the campaign, but whoever comes in will have a tough job on their hands.
Southampton face relegation rivals West Ham plus Arsenal, Chelsea and Leicester City in their next four Premier League games - excluding the re-arranged fixture with Swansea - before finishing the season at runaway leaders Manchester City.
Elsewhere in the relegation betting, dabblebet make West Brom just 1/50 (1.02) for the drop as they sit eight points adrift of safety - having lost their last seven straight games. That essentially means punters are trying to find the other two relegated teams in this market.
Stoke's defeat to Manchester City on Monday has seen the Potters clipped to 8/11 (from 4/5) while Crystal Palace are available at 2/1 (3.0). West Ham are also 2/1 (3.0) after ugly scenes marred their 3-0 loss at home to Burnley at the weekend.
The Hammers sit two points better off than Southampton but have a worse goal difference and with five Premier League games left at the London Stadium, they are certainly far from safe at this stage.