Ghana have excused the trio of goalkeeper Adam Kwarasey, midfielder Mohammed Abu and attacker Godway Donyoh from the 2019 Africa Cup of Nations qualifier against Ethiopia on Sunday.
The three players were part of a 30-man squad named by coach Kwesi Appiah for the upcoming game.
According to the GFA, Kwarasey has been "granted permission to stay [out of the team] because of a family emergency in Norway", while Nordjaelland winger Donyoh has been ruled out by injury.
There was, however, no explanation for Abu's absence, but the football governing body says the Columbus Crew man, unlike Kwarasey and Donyoh, is expected to join up with the squad for a double-header of friendlies in the USA after the Ethiopia encounter.
The Black Stars are set to face Mexico at Houston's NRG Stadium in Texas on June 28, after which they play the USA at the Pratt & Whitney Stadium in East Hartford, Connecticut three days later.
Meanwhile, in-form Chicago Fire attacker David Accam, who was originally missing in the 30-man squad, has been handed a late invite for the two friendlies.
He will link up with the squad when the team arrives in the USA.