Sami Khedira will miss Germany's friendly with England in Dortmund with an ankle problem.
The German Football Federation (DFB) tweeted the news a little over five hours before the scheduled kick-off on Wednesday.
It is understood the 29-year-old has been withdrawn as a precaution and is not suffering from a major complaint.
Juventus midfielder Khedira was part of Germany's World Cup winning side at Brazil 2014 while a Real Madrid player but was subsequently dogged by muscular problems.
This season Khedira has made 35 appearances for the reigning Serie A champions in all competitions, scoring four goals.