The draws held at Caf Headquarters in Cairo, Egypt on Tuesday saw the Nigerian champions pitched against the Rwandan side, while the Pride of Rivers got the Zambian side.
The Flying Antelopes and Pride of Rivers were kicked out of the Caf Champions League after crumbling against Zamalek and Al-Merrikh respectively.
Rayon walked over Onze Créateurs of Mali, while Zesco dumped out Burundi's Le Messager Ngozi 4-2 on aggregate.
Rangers and Rivers will host their foes in the first leg matches on the weekend of April 7-9, 2017 before traveling for the return leg a week later.
Winners of the two legs will secure a place in the money-spinning group phase of the continental second tier competition.