Tiemoue Bakayoko and Antonio Rudiger are unavailable to face Arsenal in Beijing in the International Champions Cup as Chelsea jet out to the Chinese city, Goal understands.
Rudiger will return for the matches in Singapore and he will make his debut against either Bayern Munich or Inter Milan, but Bakayoko is injured - despite being officially unveiled by the club last weekend.
Eden Hazard is also not fit to play after suffering a fractured ankle while on duty with Belgium, and he is a doubt for the start of the Premier League season.
Nemanja Matic and Diego Costa will also be left out of the tour with their futures at the club in doubt, and the likes of Nathan Ake, Ruben Loftus-Cheek and Nathaniel Chalobah will replaced by players who were on loan at other clubs last season.
Mario Pasalic, Lewis Baker, Jeremie Boga, Loic Remy and Andreas Christensen are among the names that will jet out to Asia - after a week back in training with their parent club this week at Cobham Training Centre.
Chelsea face Arsenal on July 22 in Beijing's Bird's Nest Stadium, before facing Bayern Munich and Inter in Singapore on July 25 and July 29 respectively. They will then return to England to compete in the Community Shield against Arsenal after winning the Premier League title last season.
Chelsea's squad was subsequently officially announced: Thibaut Courtois, Willy Caballero, Eduardo, Marcin Bulka, Cesar Azpilicueta, Gary Cahill, David Luiz, Andreas Christensen, Tomas Kalas, Jake Clarke-Salter, Fikayo Tomori, Marcos Alonso, Victor Moses, Cesc Fabregas, N'Golo Kante, Mario Pasalic, Lewis Baker, Kyle Scott, Pedro, Willian, Kenedy, Charly Musonda Jr, Jeremie Boga, Michy Batshuayi, Loic Remy.