Jerome Boateng limped off in the second half of Germany's semi-final against France with a suspected hamstring injury.
The Bayern Munich centre-back appeared to sustain the problem after attempting a long ball forward, with Boateng immediately signalling to the bench his discomfort.
The defender subsequently received medical treatment, only to limp off to be replaced by Shkodran Mustafi.
Boateng had played in every game of Germany's Euro 2016 campaign up to his withdrawal, even scoring in his country's 3-0 win over Slovakia in the last-16.
Mustafi, by comparison, won his 12th cap when he came on, having previously scored in the opening 2-0 win over Ukraine.