The meeting of Real Madrid and Atletico Madrid back in November brought a 3-0 win for Real at the Estadio Vicente Calderon with only one name on the scoresheet.
Cristiano Ronaldo's hat-trick was the first by a player in the Madrid derby since the Portuguese forward netted three times at the Calderon in April 2012 and the Euro 2016 winner has an excellent scoring record against Los Rojiblancos.
The 32-year-old has scored 18 times against Real Madrid's city rivals in all competitions and bet365, who are live streaming the game for UK based customers, offer him at 4/5 (1.80) to get himself on the scoresheet at anytime and at 14/1 (15.00) to net another hat-trick.
Ronaldo was rested in midweek during Madrid's 4-2 win at Leganes, as were Gareth Bale and Karim Benzema. Expect all three men to come back into the starting line-up with Benzema offered at evens (2.00) to find the back of the net and Bale priced at 13/10 (2.30).
The scorer of the most iconic goal in the history of this fixture is Sergio Ramos with the centre back's 93rd minute equaliser in the the 2014 Champions League final forever etched into the collective memory of both sets of supporters.
Ramos has an eye for the dramatic almost as keen as his eye for goal and this season Madrid's captain has excelled going forward, scoring 10 times in all competitions. The price of 11/2 (6.50) for him to do so once more looks tempting for a value bet, with the Spain international proving vital to his side during some of Madrid's biggest games this season.
For Atletico, Antoine Griezmann is playing well and scoring goals with the Frenchman netting five times in Atleti's last six La Liga matches and he is offered at 6/4 (2.50) to score at the Bernabeu. Griezmann was the matchwinner in the corresponding fixture last year with his second half strike earning Diego Simeone's men a 1-0 win.