Meetings between these two sides always have the competitive edge which a neighbourly rivalry brings, yet this week's encounter is one of the most important games between Uruguay and Argentina in recent years.
The hosts were the early leaders in the campaign after an excellent start, but their form has fallen away in alarming fashion and three successive defeats in qualifying has left them just a point above Argentina who sit in fifth place.
La Albiceleste have endured a torrid campaign by their extremely high standards and not only have the sunk to home defeats by the likes of Ecuador and Paraguay, but they have seen eternal rivals Brazil secure their place at Russia 2018 with four games to spare.
Another defeat would leave Jorge Sampaoli's side in danger of failing to claim one of the four automatic spots for next summer's World Cup, although realistically even if they finished fifth they would be massive favourites in the play-off against a nation from Oceania.
Yet there is a great deal of pride at stake for Argentina and bet365 who are live streaming the game for UK customers offer them at 6/5 (2.20) wile Uruguay at available at 23/10 (3.30).
The previous game between these two sides in the current campaign came almost exactly a year ago, with a strike from Lionel Messi enough to earn his side a 1-0 victory. Given they boast arguably the most talented collection of attacking players of any country on earth, it has has been staggering to see how badly Argentina have struggled in front of goal in World Cup qualifying.
Their total of 15 goals in 14 matches is the third lowest in the CONMENBOL table, while La Albiceste have failed to score in five of their 14 games.
Uruguay meanwhile have seen their early defensive solidity give way, with the side conceding nine goals in their last three qualifiers, although at home they remain strong winning eight of their last nine matches in this competition.
If Argentina are to rediscover their scoring touch it could be against an out for form La Celeste side and both teams to score is offered at 3/4 (1.75). However we will take the price of 6/5 (2.20) for both teams to score and over 2.5 goals which has paid out in all of Uruguay's last five qualifiers, as well as in three of Argentina's last five qualifiers on the road.