Despite being second in the CONMEBOL table, Colombia are just four points ahead of sixth placed Peru and their 0-0 draw at bottom side Venezuela last week was a frustrating result for Los Cafeteros.
A win over already-qualified Brazil would strengthened their grip on an automatic qualifying place, but that is no easy task for Jose Pekerman's side against a team they have only beaten once since 1991.
With the top four earning a direct spot in Russia and the fifth placed side going into a play-off against Oceaniac champions New Zealand, Colombia are far from guaranteed a place at the World Cup and things could get more difficult for them here.
Tuesday night sees a rampant Brazil side visit the city of Barranquilla with the five-time world champions in stunning form; Brazil have won a record breaking nine successive qualifiers, conceding just two goals during that time with Tite's side already having secured a spot at next summer's finals.
While there is not much on the line for the visitors they will want to continue their excellent run, building confidence and momentum ahead of Russia 2018 and this should be a keenly contested game.
bet365 are live streaming the match for UK-based customers and price an away win at 6/4 (2.50), while the hosts are offered at 19/10 (2.90) and the draw can be backed at 21/10 (3.10).
Since Tite took over as manager last year, Brazil have recovered some of their attacking swagger which was lost during the highly critised tenure of Dunga. Along with arguably the two best attacking fullbacks in the world in Dani Alves and Marcelo, Brazil boast the likes of Neymar, Gabriel Jesus, Philippe Coutinho and Willian up front and all four of those featured in last week's 2-0 win over Ecuador.
There are plenty of sources of goals in this Brazil team who have been finding the back of the net with serious consistency, and the Brazilians are offered at 13/8 (2.62) to score over 1.5 goals - which looks like an unmissable selection given that it has paid out in each of their last 12 qualifiers.
While Colombia are one of the more solid teams defensively in South America, Brazil recorded a 2-1 win against them a year ago, and there is plenty of value in backing the in-form visitors to get among the goals once more.