These two sides endured extremely different fortunes in the Champions League midweek, with Atletico Madrid's sedate progress thanks to a 0-0 draw against Bayer Leverkusen in stark contrast to the drama of Sevilla's exit at Leicester.
It will be tough for the Andalusians to bounce back from such a profound blow yet they must regain their focus quickly if they want to remain in third place in La Liga.
Atletico sit a place and a five points behind them in the table and a win for Diego Simeone's men on Sunday would leave Los Rojiblancos with genuine belief that they can catch their rivals from the south of the country.
As ever, bet365 are live streaming the game for UK based customers and offer a home win at the Vicente Calderon at 7/10 (1.70). Sevilla meanwhile who have drawn their last two league matches are available at 4/1 (5.00) while the draw can be backed at 14/5 (3.80).
While this has not been their best season under Simeone, Atleti remain a fierce prospect at home with the only sides to have won a league match there in the last two years being Barcelona and Real Madrid. Sevilla have not won a league game at the Calderon since 2008, and it is difficult to envisage that changing.
We saw last weekend with Barcelona's defeat at Deportivo La Coruna, how huge Champions League exertions can subsequently take their toll domestically, and Sevilla's defeat at Leicester will have had a massive psychological as well as physical impact.
The price, therefore, for a home win looks just about big enough to invest in, while backing the hosts to win to nil at 15/8 (2.88) is tempting. Sevilla have only scored one goal in their last five league visits to the Calderon while Atleti have won four of their last six home league games without conceding, meaning this selection offers real value.