Trips to Bilbao have often proved to be tricky games for Barcelona, but at the Camp Nou the Blaugrana tend to have few problems against the Basques.
Indeed, Barca are unbeaten at home against Athletic in their last 21 games - with Bilbao's last win there coming back in November 2001.
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Sergio Busquets is missing for Barcelona after picking up an injury against Chelsea in the Champions League on Wednesday night. The Catalans will also be without Luis Suarez, who is suspended.
For Athletic, full-back Mikel Balenziaga missed the Europa League defeat against Marseille on Thursday and remains a doubt.
Basques to pose few problems
It has been a disappointing season for Athletic Bilbao and their limp exit from the Europa League underlined how poorly the team have been playing.
They seem unable to raise themselves for the big occasions and they are unlikely to cause Barca any problems in a stadium where they have struggled badly this century.
Athletic have not won an away match in La Liga in 2018, losing each of their last three games on the road without getting on the scoresheet.
Tips and predictions
The absence of Luis Suarez means that perhaps Barca will not run riot, but backing a home win and under 3.5 goals in the game at 21/20 (2.05) looks a good way of investing in a routine Blaugrana victory.