Brazilian youngster Marlon deputises again for Gerard Pique in the Barcelona defence as the Blaugrana seek three home points against Eibar on the final day of the season.
Luis Enrique faces a minor defensive crisis for the Liga finale, with Pique joining Javier Mascherano and Jeremy Mathieu on the casualty list.
The coach therefores turns once more to the ex-Fluminense man, 21, who joined earlier this season and made his Liga debut during last week's win over Las Palmas.
Samuel Umtiti partners Marlon in defence, while Sergi Roberto lines up outside at right-back.
The rest of the Catalan first XI has a familiar look, with Luis Enrique's midfield and attack at full strength.
All three members of the MSN start, while Barca will look to Andres Iniesta to create a spark in the middle in a game they must win to have any chance of toppling Real Madrid to win La Liga.
Barcelona: Ter Stegen; Roberto, Marlon, Umtiti, Alba; Busquets, Rakitic, Iniesta; Messi, Suarez, Neymar. Subs: Cillessen, Denis, Arda, Paco Alcacer, Digne, Andre Gomes, Borja Lopez.