Alexis Sanchez will not start for Arsenal against Watford on Saturday, with Danny Welbeck taking the Chile international star's place.
Sanchez misses out after being rested following Chile's World Cup qualifying expolits last week in which they failed to qualify for next summer's tournament in Brazil.
Gunners boss Arsene Wenger said before the game that he would assess Sanchez's physical and mental state before deciding to whether select him for the match at Vicarage Road.
Alexandre Lacazette starts as the lead striker for the Gunners, with Alex Iwobi playing alongside Welbeck in the deeper roles.
Egypt midfielder Mohamed Elneny replaces the rested Aaron Ramsey in midfield, with Granit Xhaka keeping his place following a 2-0 victory at home to Brighton last time out.
Mesut Ozil takes his place on a strong-looking substitutes bench following his recovery from a knee inflammation injury, with Olivier Giroud, Jack Wilshere and Theo Walcott named among the subs.
Arsenal starting XI: Cech, Koscielny, Mertesacker, Monreal, Bellerin, Elneny, Xhaka, Kolasinac, Iwobi, Welbeck, Lacazette
Arsenal bench: Ospina (GK), Holding, Coquelin, Wilshere, Ozil, Walcott, Giroud.
Watford starting XI: Gomes, Mariappa, Kiko Femenía, Britos, Holebas, Cleverley, Richarlison, Kabasele, Doucouré, Pereyra, Gray
Watford bench: Karnezis (GK), Wagué, Janmaat, Watson, Capoue, Carrillo, Deeney.