Arda Turan and Rafinha Alcantara have come in for Luis Enrique's side, while Aleix Vidal receives a rare chance to impress from the start
Luis Enrique has opted to leave Neymar, Andres Iniesta and Ivan Rakitic on the bench for Barcelona against Las Palmas as he reshuffles his pack.
The Liga champions host the Canary Islanders hoping to temporarily close the gap at the top of the table to two points behind Real Madrid, who face Sevilla on Sunday.
Las Palmas are performing above expectations and currently sit eighth in the table, though Luis Enrique seems undeterred as he rotates his squad.
Aleix Vidal receives a league start for just the second time since last October, completing the backline alongside Samuel Umtiti, who replaces Gerard Pique - omitted from the squad altogether.
Andre Gomes and Rafinha Alcantara flank Sergio Busquets and support an attacking triumvirate consisting of Lionel Messi, Luis Suarez and Arda Turan.
Messi will be seeking a career-first La Liga goal against Las Palmas, who can call on Kevin-Prince Boateng - the midfielder scoring twice in six appearances against Barcelona while with AC Milan - in the centre of the park.
Barcelona XI: Ter Stegen; Vidal, Mascherano, Umtiti, Alba; Gomes, Busquets, Rafinha; Messi, Suarez, Arda
Subs: Rakitic, Cillessen, Digne, Neymar, Iniesta, Alcacer, Mathieu
Las Palmas XI: Varas, Macedo, Lemos, Garcia, Lopes; Viera, Mesa, Gomez; Boateng; El Zhar, Dominguez
Subs: Lizoain, Montoro, Artiles, Momo, Simon, Livaja, Garcia