The former Three Lions defender tells a Gatorade event that the Liverpool striker's unreal form this season will make his country's encounter with Uruguay a testing one
Both sides go into the crucial Group D encounter looking to kick-start their World Cup campaigns having lost their opening matches on Saturday.
And former Arsenal defender Keown says England must be on their guard if the Liverpool striker makes his comeback to Oscar Tabarez's side after a knee operation.
“You have to expect the unexpected with him," Keown said at the Gatorade 'Unreal Around the World' event at the Emirates Stadium.
"He’s a really difficult opponent to play against and the English players will know all about him of course.
"This game will be the significant game because they have got to beat Uruguay or at the very least get a draw."
Suarez was an unused substitute for Uruguay’s surprise 3-1 defeat to Costa Rica but Keown expects the 27-year-old to be fit and firing on Thursday.
"Is he going to be fit? I feel he will turn up so, for England’s sake, let’s just hope Suarez doesn’t have the last laugh," Keown added.
Find out more about the fuel of football at www.gatoradefootball.com or www.gssiweb.org #BeUnreal