Vicente del Bosque will revert back to the team that faced Uruguay in Spain's Confederations Cup opener for the Nigeria clash, with the exception of Victor Valdes in goal.
This means Fernando Torres and David Villa return to the bench while Andres Iniesta and Roberto Soldado are included in the starting XI.
And despite grievances admitted from players such as Xavi over the squad rotation policy which Del Bosque has implemented in the tournament, the 62-year-old says everyone will get their chance to impress.
“We have to finish the group well,” he told AS. “We are not thinking about it, but if we lose to Nigeria by more than four goals, who knows what might happen?
“We just want to focus on the game against the Nigerians and then we'll have time to think about Brazil or Italy.
“We haven't been frivolous with our selections – I've made decisions that I think are best for the team.
“It is impossible to please everyone, but I try to keep a good relationship with all the players.
“Yes, Victor Valdes will play. The plan was that if we won against Uruguay, then each goalkeeper would play in the group games.
“We have three fantastic goalkeepers.”
Spain need a point to guarantee top spot and progress to the semi-finals to face Italy, who they beat 4-0 to lift Euro 2012 trophy.
La Roja team to face Nigeria: Valdes; Arbeloa, Ramos, Pique, Jordi Alba; Busquets; Xavi, Cesc, Iniesta, Pedro; Soldado