The centre-back says he and his international colleagues are hoping to test themselves against the world's best in the coming weeks
Both teams have enjoyed winning starts to their respective campaigns and, with a 14-year gap between the two teams' last encounter, the 26-year-old believes the tournament would serve as the ideal stage to host the clash - which could be in the semi-final or final.
"I think we all want to play against Spain. For me in particular, I love to play against them here [in Brazil]," David Luiz told a press conference.
"The Spanish are a great team at the moment. They are mature and play nice football. They have many great individuals and they are a really great team."
Meanwhile, the Chelsea centre-back looked ahead to Selecao's next test against Mexico and is expecting an arduous 90 minutes against Jose Manuel de la Torre's men.
"They are a really difficult team to win against and we know they will make things very difficult. For us it is a very important game because we can go top of the group with a win."
Luiz Felipe Scolari's men face the Mexicans on Wednesday at 21:00CET.