La Roja's crucial Group I match against Belarus faces the risk of being called off after a blast left two people seriously injured and an electrical generator inoperational
Two people have been rushed to hospital after suffering burns in the explosion which has left one of three electrical generators inside the arena inoperational for the time being.
As result, La Roja's crucial clash with Georgi Kondratiev's men has been thrown into doubt, with the stadium unable to generate enough power to operate floodlights and scoreboards.
Workers have arrived at the scene in a bid to repair the damage in time but it remains unknown whether or not Friday's fixture will proceed as scheduled.
Should the clash go ahead, Vicente del Bosque's men could take a giant step toward securing automatic qualification to next summer's World Cup in Brazil by beating the eastern Europeans.
Victory would see the reigning world and European champions needing only a point in their final qualifying fixture with Georgia to pip second-placed France to top spot in Group I.
Friday's encounter is scheduled to kick off at 21.00BST.