The Arsenal midfielder starts after recovering from illness while Southampton striker Paul Lambert continues up front in the absence of Wayne Rooney and Daniel Sturridge
Rickie Lambert leads England's attack after his goalscoring debut as a substitute against Scotland, while manager Roy Hodgson opts for the experience of Steven Gerrard and Frank Lampard in the two holding midfield positions.
England starting XI: Hart; Walker, Cahill, Jagielka, Cole; Gerrard, Lampard, Wilshere; Walcott, Lambert, Welbeck.
Subs: Smalling, Ruddy, Baines, Carrick, Cleverley, Milner. Barkley, Defoe, Young, Sterling, Townsend, Forster.
Moldova starting XI: Namasco, Armas, Golovatenco, Epureanu, Ionita, Antoniuc, Dedov, Georghiev, Bulgaru, Bordian, Sidorenco.
Subs: Pascenco, Cebanu, Onica, Racu, Cebotaru, Doros, Suvorov, Boestean, Erhan, Pascenco, Grossu, Andronic.