The Manchester City star has been struggling with a knee injury and his national team's fitness staff have advised him to miss the upcoming qualifiers against Venezuela and Bolivia
The 24-year-old had originally been named in the squad for Argentina's upcoming World Cup qualifiers at home to Venezuela and a tough trip to face Bolivia in La Paz.
Aguero had been struggling with a knee injury and although he admits that his condition has improved, the team's fitness staff believe he would be better off missing out.
The striker revealed on Twitter: "My knee is better but the squad's physicians would rather have me be safe and stick with the treatments until it's completely healed.
"It's a pity to miss out on the national squad matches but I'll be cheering for Argentina from Manchester, while I finish the recovery."