Del Bosque dropped eight of the Spain side who crashed out of the World Cup in Brazil this summer in the group stages, including Gerard Pique, Juan Mata and Fernando Torres.
With David Villa, Xavi and Xabi Alonso all confirming their retirement from international football, the coach has called on Real Madrid's Isco and Barcelona defender Marc Bartra for Spain's upcoming matches against France and Macedonia.
When asked about his revamped team, Del Bosque insisted that he was looking to the future with his selection and that it has not all been doom and gloom following their Brazil embarrassment.
"The World Cup was our error, marked by sporting circumstances, but it was neither a miserable defeat nor a bad environment in Brazil, there was a good atmosphere there," he told the press.
"We did what we had to do. Now our biggest concern was and is to bring ourselves back to our best.
"The main thing is to do things with common sense. We had a generation that gave us so much success but there is no reason not to start a new generation."
La Roja will first face Didier Deschamps's France team in a friendly clash on September 4 before playing Macedonia in a European Championship qualifier four days later.