The 22-year-old Tottenham winger was in contention for a place in Roy Hodgson's England squad but he will now require surgery after damaging ligaments in his left ankle
The 22-year-old has collected five caps for the England national team having broken into the setup in 2013, scoring one goal against Montenegro at Wembley.
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A statement on the club's official website read: "Following further examination and consultation, Andros Townsend is to undergo surgery on his left ankle on Thursday after damaging ligaments during our fixture against Stoke City last Saturday.
"The injury is likely to sideline the young winger for up to 10 weeks."
The winger had struggled to break into Tim Sherwood's team after a hamstring injury kept him on the sidelines for the opening fixtures of the current Spurs manager's reign, but his form for England saw him touted for a place in the final squad of 23.
Hodgson is set to name his Three Lions squad on May 12.