The former Real Madrid playmaker had been struck by illness but made a 30-minute cameo in Germany's 1-1 draw with Italy, and Jogi Low has now decided to trial other personnelArsenal playmaker Mesut Ozil will not take part in Germany's friendly clash with England at Wembley Stadium on Tuesday night.
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"The game against England is the last chance to test tactics and personnel before the World Cup," Low said in a statement.
"Lahm, Neuer and Ozil are the absolute core, for me it's important to give other players in key positions a chance to prove themselves against a great team like England."
Ozil has recorded the joint-most assists in the Premier League since moving to the Emirates Stadium, helping Arsenal climb to top spot, but was struck by illness this week.
Meanwhile, Arsenal defender Per Mertesacker joins the squad after recovering from a virus suffered prior to the 1-0 defeat to Manchester United last weekend.