Having missed out on a place in Roy Hodgson's senior party, the pair form part of Gareth Southgate's side to face Finland and San Marino in their latest Euro 2015 qualifiers
The Manchester United and Liverpool wingers have previously been included in Roy Hodgson's senior squad but must now make do for a place in the youth side after spending much of this season on the sidelines for their clubs.
Ravel Morrison is also included despite being touted for his first full cap after some impressive performances for West Ham, while Saido Berahino will be looking to continue his fine goalscoring record at this level after also missing out on Hodgson’s squad.
Leicester City defender Liam Moore has the chance to earn a second cap one year after making his debut against Northern Ireland, while Luke Shaw and Will Hughes return to the fold after withdrawing from October's games.
However, injured duo Tom Carroll and Nathan Redmond are unavailable for the Young Lions, along with suspended captain Andre Wisdom.
England currently lead Group One after resounding 4-0 and 5-0 victories over San Marino and Lithuania, respectively.
England Under-21s squad in full:
Goalkeepers: Jonathan Bond (Watford), Jack Butland (Barnsley, on loan from Stoke City), George Long (Sheffield United)
Defenders: Eric Dier (Sporting Lisbon), Carl Jenkinson (Arsenal), Michael Keane (Manchester United), Liam Moore (Leicester City), Jack Robinson (Blackpool, on loan from Liverpool), Luke Shaw (Southampton), John Stones (Everton)
Midfielders: Nathaniel Chalobah (Nottingham Forest, on loan from Chelsea), Will Hughes (Derby County), Ravel Morrison (West Ham), James Ward-Prowse (Southampton), Tom Ince (Blackpool), Jesse Lingard (Birmingham City, on loan from Manchester United), Raheem Sterling (Liverpool), Wilfried Zaha (Manchester United)
Forwards: Saido Berahino (West Brom), Harry Kane (Tottenham), Danny Ings (Burnley), Nick Powell (Wigan, on loan from Manchester United)