Giovanni Trapattoni will give the Norwich City midfielder his first international start, while Shane Long is set to captain the Republic of Ireland in Sunday's friendly
Trapattoni has named Shane Long as captain for the tie, and the West Bromwich Albion striker will be partnered by Simon Cox as usual captain Robbie Keane is rested.
Kieran Westwood replaces David Forde in goal, while a completely overhauled back four sees Stoke City full-back Marc Wilson returning from injury, helping prove his fitness ahead of Friday's World Cup Qualifier with the Faroe Islands.
With Robbie Brady forced to withdraw from the squad, Trapattoni will deploy Andy Keogh on the right wing, while Aston Villa defender Richard Dunne is expected to play some part in the game, coming off the bench as he looks to regain fitness.
Republic of Ireland v Georgia: Kieran Westwood; Paul McShane, Richard Keogh, Damien Delaney, Marc Wilson; Andy Keogh, James McCarthy, Wes Hoolahan, James McClean; Simon Cox, Shane Long.