The right-back was substituted during his side's 2-1 defeat to Wigan on Sunday, having suffered a thigh injury.
"Debuchy has a lesion on the thigh, he is out," Deschamps told the press ahead of the game, before warning his team to focus on Friday's game before Tuesday's follow-up against world champions Spain.
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"Georgia have offensive qualities. They also defended very well against Spain. We could face the same situation.
"Georgia will come to defend well. We'll have to find opportunities to score. We'll try to have a team which takes control of the ball and creates problems. This is where we work."
Deschamps also praised Juventus midfielder Paul Pogba upon his first call-up to the national side, as well as the more experienced Real Madrid striker, Karim Benzema.
"Pogba must find his place in the group. I trust him," he added. "He represents the future and the future is today.
"Benzema is happy to be here, he's attached to the France team. He's a driving force."