The 2013-14 edition of the under-19 tournament, which has previously involved Arsenal, Chelsea, Liverpool and Tottenham, has been cancelled due to a lack of sponsorship
The annual event, which brings together Under-19 sides from some of Europe's top clubs, only began in 2011 but has now been forced to take an unscheduled break because of a lack of sponsorship.
"The level of support we have received from the football industry, media and fans has been magnificent and for that we are truly grateful," read a statement from tournament co-founders Mark Warburton and Justin Andrews.
"It is hugely disappointing that an event of this nature, designed to assist with the development of Europe's elite players, should have to take such action but we hope to be back next season with an even better tournament."
The NextGen series now faces an uncertain future, with Uefa poised to launch a Champions League-style competition aimed at the same age group next year.
It was Inter's victory in the 2011-12 edition that persuaded club president Massimo Moratti to appoint Primavera boss Andrea Stramaccioni as first team coach following the dismissal of Claudio Ranieri last year.