The quarter-finals of the NextGen Series sees a difficult fixture for Tottenham as they host a Sporting side that demolished Liverpool 4-0 in the previous round.
Chelsea, who knocked out Barcelona with a 2-0 win at the Camp Nou when down to 10 men in the round of 16, face either Juventus or Rosenborg depending on the outcome of their match.
Should the Gunners navigate an away match with Inter successfully, their reward will be a home tie against CSKA Moscow or PSV Eindhoven.
Meanwhile, Aston Villa also have a home tie against either Olympiacos or Anderlecht, with young striker Mikey Brennan in good form, having scored six goals in this year's competition.
Draw in full: Chelsea v Juventus or Rosenborg; Tottenham v Sporting; Inter or Arsenal v CSKA Moscow or PSV Eindhoven; Aston Villa v Olympiacos or Anderlecht.