Swansea winger comes in after goal-scoring cameo against UAE while the Olympic captain sits out after two games in quick succession at the Games
Fellow Welshman Craig Bellamy will take the captain's armband after two excellent performances so far at the games.
Ryan Bertrand also comes into defence in place of James Tomkins, with Micah Richards moving back into central defence and Neil Taylor moving to right-back.
La Celeste include Luis Suarez and Edinson Cavani up front but make two changes with Matias Aguirregaray replacing Emiliano Albin at the back and Tabare Viduez replacing Maximiliano Caldaza in midfield.
Team GB: Butland; Taylor, Richards, Caulker, Bertrand; Ramsey, Allen, Cleverley; Bellamy (c), Sturridge, Sinclair.
Uruguay: Campana; Arias, Coates, Rolin, Aguirregaray; Ramirez, Rodriguez, Viudez, Arevalo; Cavani, Suarez (c).