A drab performance against Algeria has prompted a series of tactical switches as Joachim Low's men bid to progress to the semi-finals at the expense of their European rivals
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Klose's selection means the Germany veteran could overtake Brazil legend Ronaldo as the World Cup's top goalscorer of all-time, if he can find the back of the net for a 16th time in the competition.
Behind Klose, Thomas Muller is set to play wide right, with Toni Kroos in an attacking midfield role and Mesut Ozil on the left.
Real Madrid's Sami Khedira will form a double-pivot with Bastian Schweinsteiger in defensive midfield.
Germany Starting XI: Neuer; Lahm, Boateng, Hummels, Howedes; Khedira, Schweinsteiger; Muller, Kroos, Ozil; Klose