The German coach believes his side are capable of achieving a significant upset and have the confidence to overcome the Red Devils on Tuesday
The US have upset the odds in the tournament so far, coming through Group G ahead of Ghana and Portugal after a 2-1 win and 2-2 draw against the two sides respectively.
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"We have enough confidence now going into this game – a very special one, a knockout game – to say we are able to beat them," the 49-year-old told a press conference.
"Belgium are one of the secret favourites in this World Cup because of the players, individual players, that they have. We have absolutely no fear at all. We feel like we are in a position now to challenge.
"We believe we have built a foundation in our team that we are able to beat them. I was definitely not as happy as with the first two games with the performance they had against Germany.
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The former Germany striker, a World Cup winner in 1990, is also hoping to be boosted by the return of Jozy Altidore, having previously suffered a hamstring strain in the opening match with Ghana.
"We are very optimistic [about Altidore's fitness]," he continued. "Every day is a big step forward. Eleven days now and he's looking better every day."