The striker has not played since undergoing keyhole surgery on a knee injury four weeks ago and will line up against the same Three Lions starting XI which lost to Italy
Luis Suarez has been included in the Uruguay starting XI for their crucial World Cup Group D fixture against England in Sao Paulo.
The Liverpool striker, who scored 31 goals in 33 Premier League games last season, has only recently recovered from a knee injury and claimed he would not play at the Arena Corinthians unless 100 per cent fit.
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"If [Suarez] plays we must consider the possibility that he's not as well as he was during the Premier League," he told reporters. "But even when not 100 per cent he is someone who can give a lot to his team.
"We thought if everything went well there was no reason for him not to play in the World Cup. He has recovered well."
Elsewhere, Uruguay are without injured captain Diego Lugano and the suspended Maxi Pereira, with Jose Maria Gimenez and Alvaro Pereira coming in instead, while Diego Forlan drops to the bench.
Meanwhile, England are unchanged from the side who lost 2-1 to Italy in their opening game, although Wayne Rooney is expected to take up a more central role.
The striker was deployed on the left of an attacking front four on Saturday as Daniel Sturridge led the line but, despite supplying the assist for England's only goal, he came under fire after a largely below-par performance.
Raheem Sterling, who played in the No.10 role in Manaus, is expected to move to the right with Danny Welbeck switching to the opposite flank.
URUGUAY: Muslera; Caceres, Gimenez, Godin, A. Pereira; Gonzalez, Arevalo Rios, Lodeiro, Rodriguez; Cavani, Suarez.
ENGLAND: Hart; Johnson, Cahill, Jagielka, Baines; Henderson, Gerrard, Sterling, Rooney, Welbeck, Sturridge