La Celeste were shocked in their Group D opener, going down 3-1 to Costa Rica, and are left with little margin for error against England in Sao Paulo on Thursday.
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"We have gone through a lot and have always survived,” Cavani told Fifa.com.
"Play-offs, difficult matches, extreme situations – and here we are. This generation has won almost everything and knows how to do so."
The bulk of the squad that reached the semi-finals in South Africa four years ago and went on to claim 2011 Copa America glory remain together, and Forlan believes this could also be a factor in Uruguay's favour.
“Of course it won't be easy but this team has been together for a long time and we know what we're capable of,” said the 35-year-old.
"We have to do our work on the pitch, play as we know [we can], and I believe that will be sufficient to achieve the results we need.”