The Barcelona forward claims victory on Tuesday would go a long way to securing La Roja's place in Brazil 2014, while revealing he is ready to play regularly for his country again
The 30-year-old Barcelona man insists Didier Deschamps' side are "the team to beat" in the group, and is expecting Les Bleus to up their game when they face the reigning world and European champions.
Speaking at the launch of a new book to raise funds for the Hospital San Juan de Dios, Villa told reporters: "It's a match between the two most important teams.
"France are the team to beat. We've started well with two wins, and it would be a big step to beat them. They're a very powerful rival, with young players who are new to the national team and eager to prove themselves against Spain."
Villa made a late appearance as a substitute in Spain's 4-0 win over Belarus last Friday, and the striker revealed he feels ready to play regularly for his country again after recovering successfully from a broken leg.
"I feel good, I've been very happy during these months because I realise that I have been lucky," he continued. "I suffered a very serious injury, many would have had to end their careers. I succeeded after many hours of work and am lucky enough to be surrounded by the best.
"I'm ready to play now, and I think everyone is with me in my club and the national team. Now I'm waiting for the decisions of my two coaches."