The Arsenal defender believes his country are in a for a tough battle against Craig Levein's men, and that they will have to suppress some experienced players if they hope to win
The Belgians currently sit top of Group A with seven points after a dominating 3-0 win over Serbia, while Scotland sit second from bottom after relinquishing a one-goal lead to fall to an agonising late defeat against Wales.
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"It's not going to be easy because they have some good players who play in the Premier League," Vermaelen told Sky Sports. "They have a lot of experience.
"We got a massive three points on Friday and we want three points on Tuesday as well."
There have also been reports that Chelsea new-boy Eden Hazard could be left out of the side to face Levein's side, but the Gunners captain insists the squad remain firmly behind their star man.
"Everyone knows his [Hazard's] qualities. I am really happy he is with the national team," the 26-year-old added . "It doesn't mean he is playing badly.
"Maybe that lack of team unity was the problem in the past but at the moment the shape of the team is better and we are getting the results."