The Bhoys midfielder anticipates some fierce battles between players who line up next to each other every week, as both sides look for first win in their World Cup qualifier
Both teams are yet to earn a win in Group A, and the former Cardiff City player is anticipating a tough night against his club-mates.
Both Ledley and Adam Matthews are likely to play for Wales, whilst the Bhoys' captain Scott Brown and James Forrest could start for Scotland.
| WORLD CUP QUALIFYING LATEST
|11/1||Wales are 11/1 with Bet365 to beat Scotland 2-0
"James up against Adam and me up against Scott Brown so there will be key battles and we will see who comes out on top.
"We play against each other in training every day and we know each other's strengths and weaknesses so it is going to be a good game and we look forward to it.
"Scott is fantastic. He is one of our better players this season. He drives the players on and tries to attack as well.
"I am going to be on my toes and it is going to be a difficult evening for me."
Meanwhile, Forrest has emphasised the boost given to the away side by the return of key players such as Steven and Darren Fletcher.
"Looking at the squad and seeing Steven Fletcher, Darren Fletcher and Scott Brown back, they are three big players and it is a boost for us in the next two games," he told reporters.
"Steven is scoring week in, week out in the Premiership and we want to play with the best players.
"He is definitely up there so we are delighted he is back in the squad."