The Napoli striker and the Cruzeiro defender will both miss the tournament semi-final on Tuesday, after failing to recover from injury
Oscar Tabarez's team qualified for the last four with a penalty-shootout victory over Argentina, after drawing 1-1 after extra time. If the Celeste can overcome Peru in La Plata it will confirm their place in the final fixture for the first time since 1999.
However, Team doctor Alberto Pan explained on Monday that they would have to face the Inca without the Napoli and Cruzeiro men, as they failed to recover in time from respective injuries.
The medic informed Radio 1010 that the pair would be unavailable for the Copa clash, and they join the suspended Perez on the unavailable list, forcing two changes from the team which downed arch-rivals Argentina. It is expected that Tabarez will bring in young centre-back Sebastian Coates for Victorino, while Walter Gargano would enter for the midfielder.
Cavani has been unable to appear for his nation since the group stage clash against Chile, due to a knee strain suffered in that game.
Possible Uruguay XI: Muslera; M. Pereira, Lugano, Coates, Caceres; A. González, Gargano (or Eguren), Arevalo Rios, A. Pereira; Suarez, Diego Forlan.