The Albiceleste take on Frank Rijkaard's men in Riyadh on November 14 and head coach Alejandro Sabella has made a number of surprising inclusions to his squad.
Latics forward Di Santo has never made a senior international appearance for his country, despite playing over 20 times for the Under-20s side. However, the 23-year-old looks set to finally get his opportunity after being called up following a string of impressive performances towards the end of last season and this term.
Magpies mainstay Coloccini has made 34 appearances for the national team and was called up to the side as recently as September when he was named in the squad for the World Cup qualifier with Paraguay.
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|200/1||Franco Di Santo is 200/1 with Bet365 to be the Premier League's top goalscorer|
The Premier League pair are joined in the squad by Barcelona star Lionel Messi and fellow regulars Javier Mascherano and Gonzalo Higuain.
Argentina travel home to Buenos Aires to face arch rivals Brazil in another friendly international just a week after their trip to the Middle East.
Argentina squad in full to face Saudi Arabia:
Goalkeepers: Sergio Romero (Sampdoria), Mariano Andujar (Catania), Cristian Alvarez (Espanyol)
Defenders: Hugo Campagnaro (Napoli), Pablo Zabaleta (Manchester City), Marcos Rojo (Sporting Lisbon), Federico Fernandez (Napoli), Ezequiel Garay (Benfica), Luciano Monzon (Lyon), Fabricio Coloccini (Newcastle)
Midfielders: Fernando Gago (Valencia), Javier Mascherano (Barcelona), Angel Di Maria (Real Madrid), Augusto Fernandez (Celta Vigo), Enzo Perez (Benfica), Tino Costa (Valencia), Ricky Alvarez (Inter), Fabian Rinaudo (Sporting Lisbon)
Forwards: Lionel Messi (Barcelona), Sergio Aguero (Manchester City), Gonzalo Higuain (Real Madrid), Eduardo Salvio (Benfica), Franco Di Santo (Wigan)