Chelsea duo Fernando Torres and Juan Mata both start for Spain against South Korea on Wednesday, along with Liverpool goalkeeper Pepe Reina.
Betis midfielder Benat and Malaga full-back Nacho Monreal, both left out of Spain's final squad for Euro 2012, also get a chance to impress in the absence of Barcelona's players - still on holiday.
Real Madrid trio Alvaro Arbeloa, Raul Albiol and Sergio Ramos all start in defence, while Malaga midfielder Santi Cazorla is also selected.
Coach Vicente del Bosque is likely to give several substitues a run-out as well in this match.
Spain (4-3-3): Reina; Arbeloa, Albiol, Ramos, Monreal; Xabi Alonso, Benat, Cazorla; Mata, Silva, Torres
Subs: Casillas, De Gea, Dominguez, Jordi Alba, Bruno, Juanfran, Javi Garcia, Navas, Adrian, Soldado, Negredo
South Korea (4-4-2): Jin-Hyeon; Hyo-Jin, Yong-Hyung, Jung-Soo, Joo-Ho; Do-Heon, Tae-Hee, Ja-Cheol, Ki-Hun; Heung-Min, Dong-Won