Wednesday's game saw irregular betting patterns and a highly controversial decision just before the final whistle, prompting football's governing body to take swift action
The match ended 4-1 to Nigeria, although Manchester City defender Pablo Zabaletta – who was captaining the team – led a weakened team in Abuja for the friendly as part of their preparation for the Copa America.
Concerns have been raised by betting patterns which took place during the game, particularly before Argentina clinched a consolation goal in added time.
Just before Argentina’s late goal there was a surge in gambling which seemed to predict the fifth goal.
Despite only five minutes awarded as stoppage time, referee Ibrahim Chaibou allowed play to continue till the 98th minute when a controversial handball decision led to Argentina pulling a goal back from the penalty spot through Wigan flop Mauro Boselli.
A Fifa spokesman said: "Fifa can confirm that this match between Nigeria and Argentina was one that we had an active interest in, and forms part of a wider ongoing Fifa investigation."
Sepp Blatter, Fifa President, has already signalled his intentions to clamp down on the ‘plague’ of match fixing and this new investigation will form part of the zero-tolerance campaign.
Match official Chaiboi, who refereed the game on Wednesday, was in charge of a September 7 friendly between Bahrain and a ‘fake’ Togo team, another game under Fifa investigation.