The San Jose Earthquakes forward equalled the MLS mark with 27 goals this season, seeing off Thierry Henry and Graham Zusi to win the league's top individual award
Wondolowski was the strong favourite to win the league's MVP award, and he did that in a landslide vote, capturing the division's top individual honour on Thursday.
Wondolowski's 27-goal season equalled Roy Lassiter's single-season MLS haul set in the inaugural 1996 campaign and helped propel the Earthquakes to the Supporters' Shield.
Wondolowski, a late pick in the 2005 MLS Supplemental Draft, was traded from the Houston Dynamo to San Jose in 2009. He has led the MLS goalscoring charts for the last thee years (he tied with Dwayne De Rosario last season and missed out on the Golden Boot due to the assists tiebreaker), amassing 61 goals in that time after netting just seven goals in the previous five seasons.
The California native beat New York Red Bulls forward Thierry Henry, Sporting Kansas City midfielder Graham Zusi and Houston midfielder Brad Davis to win the prize, becoming the first Earthquake to do so.
The 29-year-old Wondolowski received 91.23 per cent of the club vote, 96.97% of the media vote and 70.83% of the player vote to coast to victory.
Wondolowski becomes the fifth United States-born player to win the MLS MVP award, joining Landon Donovan, Taylor Twellman, Jason Kreis and Tony Meola. Another American to win the gong was the Yugoslavia-born Preki, who did so in 1997 and 2003.